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Article

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor prote...

Jie Qu, Xue-You Tao, Peng Teng, Yan Zhang, Ci-Liang Guo… in Journal of Neuroinflammation (2017)