24 Result(s)
within
Chunyuan **
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessA whole-slide foundation model for digital pathology from real-world data
Digital pathology poses unique computational challenges, as a standard gigapixel slide may comprise tens of thousands of image tiles1–3. Prior models have often resorted to subsampling a small portion of tiles fo...
-
Article
Open AccessAssociations of hyperthyroidism with epilepsy: a Mendelian randomization study
Prior studies have revealed an increased susceptibility to epilepsy in hyperthyroid individuals, but the genetic basis of the hyperthyroidism–epilepsy relationship is not fully comprehended, prompting this stu...
-
Article
Open AccessS-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens
Oxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS). The microbial infection-induced excessive RNS damages many bio...
-
Article
Open AccessGlucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages
The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood. Macrophages are the primary targets by which GCs exert pharmacological effects and perform critical functions in adipose tis...
-
Article
Open AccessRemnant cholesterol can identify individuals at higher risk of metabolic syndrome in the general population
Remnant cholesterol (RC) is a highly atherogenic lipid. Previous studies have shown that RC was closely associated with many metabolism-related diseases. However, the relationship of RC with metabolic syndrome...
-
Article
Open AccessMyristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate invading pathogens and serves as a self-limiting mechanism of STING-induced interferon (IFN) responses. Thus, the ...
-
Article
Open AccessEffects of aspect on phenology of Larix gmelinii forest in Northeast China
The response of vegetation phenology to global climate change is one of the main forms in terrestrial ecosystem change, the study of vegetation phenology is an important complement to the understanding of how ...
-
Article
Open AccessTRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), including phosphorylation and ubiquitination, control NLRP3 pr...
-
Article
Open AccessQuantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (...
-
Article
Open AccessAssessment of the embolization effect of temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels in the rabbit renal artery by CT perfusion and confirmed by macroscopic examination
Transcatheter embolization is an important treatment method in clinical therapy, and vascular embolization material plays a key role in embolization. The temperature-sensitive p(N-isopropylacrylamide-co-butyl ...
-
Article
Open AccessUAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
NOD-like receptor protein 3 (NLRP3) detects microbial infections or endogenous danger signals and activates the NLRP3 inflammasome, which has important functions in host defense and contributes to the pathogen...
-
Article
Open AccessDesign of highly efficient deep-blue organic afterglow through guest sensitization and matrices rigidification
Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited stat...
-
Article
Open AccessThe harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs
Epidemiological researches have demonstrated the relationship between PM2.5 exposure and increased morbidity and mortality of cardiovascular injury. However, no effective therapeutic method was established. The p...
-
Article
Open AccessPhenotypic and functional alterations of pDCs in lupus-prone mice
Plasmacytoid dendritic cells (pDCs) were considered to be the major IFNα source in systemic lupus erythematosus (SLE) but their phenotype and function in different disease status have not been well studied. To...
-
Article
Design, construction and ocean testing of wave energy conversion system with permanent magnet tubular linear generator
In this paper, the design, construction and ocean testing of a wave energy conversion system are studied. Based on the motion characteristics of double buoys in ocean waves, a wave energy conversion system wit...
-
Article
Erratum: Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
Nature 517, 89–93 (2015); doi:10.1038/nature13801 In this Letter, author J.-L.C. was inadvertently missing one of their affiliations; they should also have been associated with affiliation number 2 (St. Giles ...
-
Article
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.
-
Article
Open AccessUnambiguous observation of shape effects on cellular fate of nanoparticles
Cellular fate of nanoparticles is vital to application of nanoparticles to cell imaging, bio-sensing, drug delivery, suppression of drug resistance, gene delivery and cytotoxicity analysis. However, the curren...
-
Article
Open AccessTailoring terahertz plasmons with silver nanorod arrays
Plasmonic materials that strongly interact with light are ideal candidates for designing subwavelength photonic devices. We report on direct coupling of terahertz waves in metallic nanorods by observing the re...
-
Article
Time-division phase modulated single-photon interference in a Sagnac interferometer
We introduce a stable, long-distance singlephoton Sagnac interferometer, which has a balanced configuration to efficiently compensate phase drift caused by change of the fiber-optic path. By using time-divisio...
