30 Result(s)

Article

The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice

Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Develo** high-NUE rice cultivars through balancing nitrogen uptake and the formation...

Wei Wu, **aoou Dong, Gaoming Chen, Zhixi Lin, Wenchao Chi, Weijie Tang… in Nature Genetics (2024)

Article

Map** the Behavioral Signatures of Shank3b Mice in Both Sexes

Autism spectrum disorders (ASD) are characterized by social and repetitive abnormalities. Although the ASD mouse model with Shank3b mutations is widely used in ASD research, the behavioral phenotype of this model...

**g**g Liu, Jialin Ye, Chunyuan Ji, Wenting Ren, Youwei He… in Neuroscience Bulletin (2024)

Article

The advances of adjuvants in mRNA vaccines

The remarkable success of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has propelled the rapid development of this vaccination technology in recent years. ...

Chunyuan **e, Ruhui Yao, **aojun **a in npj Vaccines (2023)

Article

ARPC5 acts as a potential prognostic biomarker that is associated with cell proliferation, migration and immune infiltrate in gliomas

Gliomas are the most common malignant brain tumors, with powerful invasiveness and an undesirable prognosis. Actin related protein 2/3 complex subunit 5 (ARPC5) encodes a component of the Arp2/3 protein comple...

Yue Ming, Chunyuan Luo, Beihong Ji, Jian Cheng in BMC Cancer (2023)

Article

HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression

Circular RNAs (circRNAs) play an important role in the progression of non-small cell lung cancer (NSCLC), especially under tumor hypoxia. However, the precise functions and underlying mechanisms of dysregulate...

Dong Wu, Tingting Chen, Xuanna Zhao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Future study for the urinary histidine adduct derived from pyrrolizidine alkaloids is warranted

Lin Zhu, Chunyuan Zhang, Jiang Ma, Yisheng He, Ge Lin in Archives of Toxicology (2021)

Article

Develo** urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human

Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Currently, a definitive diagnostic method for PA-induced liver injury (PA-ILI)...

Lin Zhu, Chunyuan Zhang, Wei Zhang, Qingsu **a, Jiang Ma, **n He… in Archives of Toxicology (2021)

Article

Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions

N⁶-methyladenosine (m⁶A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called “writers”, “erasers”, and “readers”. m⁶A has been demonstrated to exert critical molecular functions in ...

**n Wang, Rui Ma, **lin Zhang, Lian Cui, Yangfeng Ding, Weimin Shi… in Molecular Cancer (2021)

Article

The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poor...

**nfang Huang, Shumeng Hao, Junli Liu, Yuanyuan Huang… in Cellular & Molecular Immunology (2021)

Article

Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS pat...

Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang… in BMC Neuroscience (2021)

Article

Effects of the Lower Airway Secretions on Airway Opening Pressures and Suction Pressures in Critically Ill COVID-19 Patients: A Computational Simulation

In patients with critically ill COVID-19 pneumonia, lower airways are filled with plenty of highly viscous exudates or mucus, leading to airway occlusion. The estimation of airway opening pressures and effecti...

Zhenglong Chen, Ming Zhong, Li Jiang, Nanshan Chen… in Annals of Biomedical Engineering (2020)

Article

Integrated analysis of 34 microarray datasets reveals CBX3 as a diagnostic and prognostic biomarker in glioblastoma

Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, pr...

Siqi Wang, Fang Liu, Yuhui Wang, Wenliang Fan… in Journal of Translational Medicine (2019)