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Article
Open AccessAstrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
Ischemic stroke can cause secondary myelin damage in the white matter distal to the primary injury site. The contribution of astrocytes during secondary demyelination and the underlying mechanisms are unclear....
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Article
Open AccessSIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs
Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 expressed on gastric pit cells in the stoma...
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Article
Open AccessDifferent expression pattern of human cytomegalovirus-encoded microRNAs in circulation from virus latency to reactivation
Human cytomegalovirus (HCMV) is a beta-hersvirinae that has a high latent infection rate worldwide and can cause serious consequences in immunocompromised patients when reactivation; however, the mechanism of ...
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Article
Open AccessGender difference analysis of Xp11.2 translocation renal cell carcinomas’s attack rate: a meta-analysis and systematic review
Xp11.2 translocation renal cell carcinoma (tRCC) is recently recognized. As Xp11.2 tRCC involved gene translocation and fusion in X chromosome and the number of X chromosomes in female is twice of male, we won...
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Article
Open AccessCharacterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018
Vancomycin-resistant Enterococcus spp. (VRE) have spread all over the world. The present study aims to investigate the species distribution, specimen type and susceptibilities of Enterococcal species collected fr...
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Article
Open AccessAltered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents
Circulating microRNAs (miRNAs) are exceptionally stable molecule markers in extracellular environments for various diseases. Importantly, some circulating miRNAs that were encapsulated in extracellular microve...
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Article
Open AccessCirculating miR-200a is a novel molecular biomarker for early-stage renal cell carcinoma
Circulating microRNAs (miRNAs) have been recognized as novel molecular markers for renal cell carcinoma (RCC) diagnosis. However, the clinical impact of circulating miRNA has rarely been evaluated for the earl...
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Article
Open AccessAssociating transcriptional regulation for rapid germination of rapeseed (Brassica napus L.) under low temperature stress through weighted gene co-expression network analysis
Slow germination speed caused by low temperature stress intensifies the risk posed by adverse environmental factors, contributing to low germination rate and reduced production of rapeseed. The purpose of this...
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Article
Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling
Circulating exosomal microRNAs (miRNAs) are valuable biomarker candidates; however, information on the characterization and mutual agreement of commercial kits for circulating exosomal miRNA profiling is scarc...
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Article
Open AccessDoes the school cutoff date cause the disadvantage for children born in July and August?
Compulsory education systems usually specify a cutoff date regulating the precise age for entry into primary school. Existing literature from the USA and Europe has demonstrated that children born just before ...
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Article
Open AccessPU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib
Sorafenib is currently the only systemic agent approved for treatment of advanced hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib remains a great challenge with respect ...
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Article
Open AccessCharacterization of the complete mitochondrial genomes of Maiestas dorsalis and Japananus hyalinus (Hemiptera: Cicadellidae) and comparison with other Membracoidea
Only six mitochondrial genomes (mitogenomes) have been previously published for Cicadellidae, the largest family of Hemiptera. This study provides complete, annotated mitogenomes of two additional cicadellid, ...
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Article
Open AccessDistinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients
Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of v...
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Article
Open AccessTime-course responses of circulating microRNAs to three resistance training protocols in healthy young men
Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-...
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Article
Quantitative Analysis of Toosendanin in the Fruit of Melia toosendan Sieb. Et Zucc (Meliaceae) by High-Performance Liquid Chromatography Coupled with Charged Aerosol Detection
In this work, a simple and rapid high-performance liquid chromatography coupled with charged aerosol detector (HPLC-CAD) method was first developed for the quantitation of toosendanin, the major constituent of...
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Article
Open AccessSystematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles ...
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Article
Open AccessIncreased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus
Circulating microRNAs (miRNAs) are emerging biomarkers for type 2 diabetes mellitus (T2DM). However, a comprehensive characterization of the serum miRNA profile in patients with T2DM-associated microvascular d...
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Article
Open AccessInfluence of a high-altitude hypoxic environment on human plasma microRNA profiles
Circulating microRNAs (miRNAs) are promising disease biomarkers. However, the influence of high-altitude hypoxic environments on plasma miRNA profiles remains unknown. This study included a total of 509 plasma...
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Article
Open AccessA panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma
Circulating microRNAs (miRNAs) are emerging as clinically useful tools for cancer detection; however, little is known about their early diagnostic impact on RCC. The levels of 754 serum miRNAs were initially d...
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Article
Open AccessCommon and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1
How polyphagous herbivores up-regulate their counterdefense genes in response to a broad range of structurally different allelochemicals remains largely unknown. To test whether this is accomplished by having ...
