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Article
Open AccessRNA-seq reveals novel mechanistic targets of Livin in bladder cancer
Bladder cancer is a very common malignancy with a high recurrence rate. The survival of patients with muscle-invasive bladder cancer is poor, and new therapies are needed. Livin has been reported to be upregul...
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Article
Visual analysis of the morphological features and polysaccharide distribution of raw ramie and their influence on degumming
The morphological features of raw ramie and the distribution of polysaccharides on such features were investigated using various microscopes to reveal the pivotal factors that influence microbial degumming eff...
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Article
Open AccessA convenient, rapid and efficient method for establishing transgenic lines of Brassica napus
Brassica napus is an important oilseed crop that offers a considerable amount of biomass for global vegetable oil production. The establishment of an efficient genetic transformation system with a convenient tran...
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Article
Open AccessTranscriptional reprogramming strategies and miRNA-mediated regulation networks of Taxus media induced into callus cells from tissues
Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these limitations, Taxus callus cells induced through 6 months of c...
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Article
Open AccessNew different origins and evolutionary processes of AP2/EREBP transcription factors in Taxus chinensis
Taxus spp. produces the anticancer drug, taxol, and hence is planted as an industrial crop in China. APETALA2/ethylene response element binding proteins (AP2/EREBPs) are the key regulators of plant development, g...
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Article
Open AccessCa2+ imaging and gene expression profiling of Lonicera Confusa in response to calcium-rich environment
As a medicinal plant widely planted in southwest karst of China, the study of adaptation mechanisms of Lonicera confusa, especially to karst calcium-rich environment, can provide important theoretical basis for r...
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Article
Open AccessTranscriptome-wide identification and screening of WRKY factors involved in the regulation of taxol biosynthesis in Taxus chinensis
WRKY, a plant-specific transcription factor family, plays important roles in pathogen defense, abiotic cues, phytohormone signaling, and regulation of plant secondary metabolism. However, little is known about...
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Article
Open AccessSmooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events
Transforming growth factor (TGF)-β signaling disorder has emerged as a common molecular signature for aortic aneurysm development. The timing of postnatal maturation plays a key role in dictating the biologica...
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Article
A systematic approach to expound the variations in taxane production under different dissolved oxygen conditions in Taxus chinensis cells
Our results provide an evidence that the changes in taxane production caused by dissolved oxygen shifts could be associated with the global variations in the cell central carbon metabolism. ...
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Article
Open AccessMurine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transge...
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Article
Two jasmonate-responsive factors, TcERF12 and TcERF15, respectively act as repressor and activator of tasy gene of taxol biosynthesis in Taxus chinensis
Methyl jasmonate (MeJA) is one of the most effective inducers of taxol biosynthetic genes, particularly the tasy gene. However, the mechanism underlying the regulation of tasy by MeJA is still unknown. In this st...
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Article
Retraction Note to: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics
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Article
RETRACTED ARTICLE: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics
This study aimed to explore the underlying molecular mechanisms of idiopathic Parkinson’s disease (IPD) by bioinformatics analysis. Gene expression profile GSE34516 was download...
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Article
A green protocol to prepare monodisperse poly(TMPTMA–styrene) microspheres by photoinitiated precipitation polymerization in low-toxicity solvent
To prepare monodisperse polymer microspheres under mild conditions, a green protocol is set up by means of photoinitiated precipitation polymerization. The work is carried out with three novel parameters, incl...
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Article
Anatomical adaptations of the xerophilous medicinal plant, Capparis spinosa, to drought conditions
Capparis spinosa is a plant that grows in dry and arid environments. As far as can be ascertained, no comprehensive studies on how the leaf, stem and root structures adapt to drought conditions h...
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Article
Assessment of genetic and epigenetic variation during long-term Taxus cell culture
Gradual loss of secondary metabolite production is a common obstacle in the development of a large-scale plant cell production system. In this study, cell morphology, paclitaxel (Taxol®) biosynthetic ability, and...
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Article
Lonicera confusa has an anatomical mechanism to respond to calcium-rich environment
Calcium (Ca) is an important nutrient element for plant growth and development. Nevertheless, excessive Ca restricts plant communities in Ca-rich environments. Lonicera confusa DC. is one species adapted to Ca-ri...
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Article
Melt synthesis and characterization of poly(L-lactic acid) chain linked by multifunctional epoxy compound
High molecular weight(Mw) poly(L-lactic acid)s(PLLAs) were synthesized using multifunctional epoxy compound(Joncryl-ADR4370) as chain extender. The products were characterized by gel permeation chromatography(...
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Article
In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)
The degradation of butanediamine-grafted poly(DL-lactic acid) polymers (BDPLAs) in vitro together with PDLLA and maleic anhydride-grafted poly(DL-lactic acid) polymers (MPLAs) was investigated by observation of t...
