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  1. Article

    Open Access

    Culture media selection and feeding strategy for high titer production of a lentiviral vector by stable producer clones cultivated at high cell density

    The growing interest in the use of lentiviral vectors (LVs) for various applications has created a strong demand for large quantities of vectors. To meet the increased demand, we developed a high cell density ...

    Chun Fang Shen, Sonia Tremblay in Bioprocess and Biosystems Engineering (2022)

  2. No Access

    Article

    Clinical and genetic analysis for four Chinese families with Prader–Willi syndrome

    Prader–Willi syndrome (PWS) is a complex, genetic, multisystem disorder. Its major clinical features include neonatal hypotonia and failure to thrive, mental retardation, hypogonadism, short hands and feet, hy...

    Yu-wen Zhang, Hui-ying Jia, Jie Hong, Yan Ge, Hui-jie Zhang, Chun-fang Shen in Endocrine (2009)

  3. No Access

    Article

    Existence of three positive solutions for some second-order m-point boundary value problems

    By using fixed-point theorems, some new results for multiplicity of positive solutions for some second order m-point boundary value problems are obtained.The associated Green’s function of these problems are a...

    Liu Yang, Chun-fang Shen in Acta Mathematicae Applicatae Sinica, English Series (2008)

  4. No Access

    Article

    Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production

    Yeastolate is effective in promoting growth of insect cell and enhancing production of recombinant protein, thus it is a key component in formulating serum-free medium for insect cell culture. However, yeastol...

    Chun Fang Shen, Taira Kiyota, Barbara Jardin, Yasuo Konishi, Amine Kamen in Cytotechnology (2007)

  5. No Access

    Article

    The interplay of insulin resistance and β-cell dysfunction involves the development of type 2 diabetes in Chinese obeses

    Type 2 diabetes mellitus (T2DM) is a heterogeneous disorder characterized by defects in insulin secretion and action and obesity plays an important role in the deterioration of glucose metabolism. In the prese...

    Jie Hong, Wei-Qiong Gu, Yi-Fei Zhang, Yi-Sheng Yang, Chun-Fang Shen, Min Xu in Endocrine (2007)

  6. No Access

    Article

    Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome

    Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1 cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndr...

    Yi-fei Zhang, Yi-sheng Yang, Jie Hong, Wei-qiong Gu, Chun-fang Shen, Min Xu in Endocrine (2006)

  7. No Access

    Article

    Fate of explosives and their metabolites in bioslurrytreatment processes

    Microcosm tests simulating bioslurry reactors with 40% soilcontent, containing high concentrations of TNT and/or RDX,and spiked with either [14C]-TNT or[14C]-RDX were conducted to investigate the fate ofexplosive...

    Chun Fang Shen, Serge R. Guiot, Sonia Thiboutot, Guy Ampleman in Biodegradation (1998)

  8. No Access

    Article

    Fate of explosives and their metabolites in bioslurry treatment processes

    Microcosm tests simulating bioslurry reactors with 40% soilcontent, containing high concentrations of TNT and/or RDX,and spiked with either 14C]-TNT or14C]-RDX were conducted to investigate the fate ofexplosives ...

    Chun Fang Shen, Serge R. Guiot, Sonia Thiboutot, Guy Ampleman in Biodegradation (1997)

  9. No Access

    Article

    Properties of anaerobic granular sludge as affected by yeast extract, cobalt and iron supplements

    The effect of yeast extract (YE), iron (Fe) and cobalt (Co) on anaerobic bacterial granules grown in eight laboratory-scale upflow anaerobic sludge blanket reactors was investigated using a factorial design. T...

    Chun Fang Shen, Naim Kosaric, Roman Blaszczyk in Applied Microbiology and Biotechnology (1993)