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Article
Open AccessAligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus
Hepatitis B virus (HBV) quasispecies are crucial in the pathogenesis of chronic liver disease. Next-generation sequencing (NGS) is powerful for identifying viral quasispecies. To improve map** quality and si...
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Article
Open AccessMiningABs: mining associated biomarkers across multi-connected gene expression datasets
Human disease often arises as a consequence of alterations in a set of associated genes rather than alterations to a set of unassociated individual genes. Most previous microarray-based meta-analyses identifie...
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Article
Open AccessAn efficient method for mining cross-timepoint gene regulation sequential patterns from time course gene expression datasets
Observation of gene expression changes implying gene regulations using a repetitive experiment in time course has become more and more important. However, there is no effective method which can handle such kin...
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Article
Open AccessMining differential top-k co-expression patterns from time course comparative gene expression datasets
Frequent pattern mining analysis applied on microarray dataset appears to be a promising strategy for identifying relationships between gene expression levels. Unfortunately, too many itemsets (co-expressed ge...
