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Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Open AccessGlutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK
Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance. This study develops a compound, JMF4073, inhibiting thymidy...
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Article
Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan
Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.
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Author Correction: Entropy-driven charge-transfer complexation yields thermally activated delayed fluorescence and highly efficient OLEDs
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Open AccessA Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.
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The Improvement in Corrosion Resistance of Electroless Ni-P Coating on Micro-arc Oxidized AZ31 Alloy Prepared with Sodium Dodecyl Sulfate Additive and Post-supercritical CO2 Mixed Electrolyte
In this study, AZ31 Mg alloy was employed as the substrate and the widely used micro-arc-oxidation (MAO) coating was first prepared on its surface. For enhancing the corrosion and wear resistance, the electrol...
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Open AccessCaries preventing efficacy of new Isomalt-containing mouthrinse formulations: a microbial study
The effectiveness of an Isomalt-containing mouthrinse to prevent caries development was investigated.
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Open AccessUse of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å
While cryogenic electron microscopy (cryo-EM) is fruitfully used for harvesting high-resolution structures of sizable macromolecules, its application to small or flexible proteins composed of small domains lik...
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Open AccessBias polarity dependent low-frequency noise in ultra-thin AlOx-based magnetic tunnel junctions
We exploit bias polarity dependent low-frequency noise (LFN) spectroscopy to investigate charge transport dynamics in ultra-thin AlOx-based magnetic tunnel junctions (MTJs) with bipolar resistive switching (RS). ...
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Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
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Acoustic Vortex-Assisted Thrombolysis Treatment in a Pulmonary Embolism Model Using a Miniature Ultrasound Catheter
Pulmonary embolism (PE) occurs when a blood clot, usually from the deep veins of the legs, travels through the bloodstream and becomes lodged in one of the arteries of the lungs. This blockage can be life-thre...
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Open AccessGenetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study
This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based...
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Open AccessSARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
The aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may initiate cytokine cascades and correlate the clinical characteristics of...
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Open AccessTeachers’ perceptions of teaching science with technology-enhanced self-regulated learning strategies through the DECODE model
This study investigates the nuanced interplay between self-regulated learning (SRL) and technological pedagogical content knowledge (TPACK) among 192 Taiwanese voluntary pre-service and in-service teachers, se...
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Open AccessDiastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department
Given the scarcity of studies analyzing the clinical predictors of pediatric septic cases that would progress to septic shock, this study aimed to determine strong predictors for pediatric emergency department...
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Article
Improving the electro-optical properties of cholesteric liquid crystal devices via cellulose nanoparticle dopants
In the presence of a strong electric field, helices in a cholesteric liquid crystal (CLC) phase might be unwound, leaving liquid crystal (LC) molecules parallel to the electric field, thereby realizing transpa...
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Article
Muckenhoupt-Type Weights in Bessel Setting
Fix \(\lambda >-1/2\) λ > - ...
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Open AccessHyperpolarized [1-13C]-pyruvate MRS evaluates immune potential and predicts response to radiotherapy in cervical cancer
Monitoring pyruvate metabolism in the spleen is important for assessing immune activity and achieving successful radiotherapy for cervical cancer due to the significance of the abscopal effect. We aimed to exp...
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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia
The nine different membrane-anchored adenylyl cyclase isoforms (AC1–9) in mammals are stimulated by the heterotrimeric G protein, Gαs, but their response to Gβγ regulation is isoform specific. In the present stud...
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Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical for neutrophil chemotaxis and cancer metastasis. PI3Kγ is a...
