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Open AccessLocalized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Longitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for develo** novel therapeutics and pathobiological mechanism discovery underlying brain AVM progression and rupture. The sus...
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Open AccessGSTA4 mediates reduction of cisplatin ototoxicity in female mice
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α...
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Open AccessLoss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP+ to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitoc...
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Open AccessCorrection: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Nature Communications 8 Article number: 14477 (2017); Published: 16 February 2017; Updated: 18 August 2017 In the References section of this Article, incorrect papers are cited for references 4, 5, 7, 9, 10, 1...
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Open AccessMitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in obese individuals. Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the pred...
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Open AccessIntraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study
Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction. Especially, it is cr...
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Age-Related Hearing Loss: Mitochondrial Biochemical Pathways and Molecular Targets
Aging is characterized by a general decline in physiological function that leads to organism dysfunction, and eventually to death (Proc Natl Acad Sci USA 91(23):10771-10778, 1994). Hearing loss is a common fea...
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VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2
Arteriovenous malformation (AVM) refers to a vascular anomaly where arteries and veins are directly connected through a complex, tangled web of abnormal AV fistulae without a normal capillary network. Heredita...
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Reference Work Entry In depth
Update on the Free Radical Theory of Aging – The Role of Oxidative Stress in Age-Related Hearing Loss
Age-related hearing loss (AHL) is a common feature of aging and is characterized by an age-associated decline of hearing function primarily associated with loss of sensory hair cells and spiral ganglion neuron...
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Article
Antigenicity of the region encoded by exon8 of the human serine protease, HtrA2/Omi, is associated with its protein solubility
HtrA2/Omi, a mitochondrial serine protease, is pivotal in regulating apoptotic cell death. To determine the location of antigenic determinants in HtrA2/Omi, we expressed a series of the N-terminally truncated Htr...
