6 Result(s)
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Christopher L Plaisier
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Article
Open AccessIntegrated molecular and multiparametric MRI map** of high-grade glioma identifies regional biologic signatures
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis...
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Article
Open AccessMolecular subtypes of ALS are associated with differences in patient prognosis
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood clinical heterogeneity, underscored by significant differences in patient age at onset, symptom progression, therapeuti...
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Article
Open AccessN6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis
Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To identify new regulators of erythropoiesis, we utilize a functional genomic screen ...
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Article
Open AccessBicluster Sampled Coherence Metric (BSCM) provides an accurate environmental context for phenotype predictions
Biclustering is a popular method for identifying under which experimental conditions biological signatures are co-expressed. However, the general biclustering problem is NP-hard, offering room to focus algorit...
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Open AccessEvolution of context dependent regulation by expansion of feast/famine regulatory proteins
Expansion of transcription factors is believed to have played a crucial role in evolution of all organisms by enabling them to deal with dynamic environments and colonize new environments. We investigated how ...
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Open AccessA nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia
Familial combined hyperlipidemia (FCHL) is a common lipid disorder characterized by the presence of multiple lipoprotein phenotypes that increase the risk of premature coronary heart disease. In a previous stu...
