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Article
Open AccessFeasibility and performance of spin-echo EPI MR elastography at 3 Tesla for staging hepatic fibrosis in the presence of hepatic iron overload
To assess the feasibility and performance of MR elastography (MRE) for quantifying liver fibrosis in patients with and without hepatic iron overload.
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Article
Open AccessRoutine Endoscopy Prior to Surgical Ostomy Closure: An Obsolete Concept
Closure of temporary diverting ostomies is commonly preceded by an endoscopic study of the colonic mucosa and anastomosis, despite lacking evidence of its relevance and impact on subsequent operative management.
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Article
Open AccessValidation of hypermethylated DNA regions found in colorectal cancers as potential aging-independent biomarkers of precancerous colorectal lesions
We previously identified 16,772 colorectal cancer-associated hypermethylated DNA regions that were also detectable in precancerous colorectal lesions (preCRCs) and unrelated to normal mucosal aging. We have no...
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Article
Open AccessAssessment of hepatic fibrosis and inflammation with look-locker T1 map** and magnetic resonance elastography with histopathology as reference standard
To compare the diagnostic performance of T1 map** and MR elastography (MRE) for staging of hepatic fibrosis and grading inflammation with histopathology as standard of reference.
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Article
Open AccessA systematic review of the perforated duodenal diverticula: lessons learned from the last decade
The perforated duodenal diverticulum remains a rare clinical entity, the optimal management of which has not been well established. Historically, primary surgery has been the preferred treatment modality. This...
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Article
Open AccessEfficient treatment of esophageal nutrition bezoars: dissolution outmatches removal—the Zurich approach
Enteral feed bezoars are difficult to treat and can lead to serious adverse events. There is no standardized treatment approach and various strategies have been suggested. We herein describe three cases of suc...
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Article
Open AccessFunctional syndromes and symptom-orientated aftercare after esophagectomy
Surgery is the cornerstone of esophageal cancer treatment but remains burdened with significant postoperative changes of gastrointestinal function and quality of life.
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Open AccessEarly diagnosis is associated with improved clinical outcomes in benign esophageal perforation: an individual patient data meta-analysis
Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time b...
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Article
Diagnostic accuracy of texture analysis and machine learning for quantification of liver fibrosis in MRI: correlation with MR elastography and histopathology
To compare the diagnostic accuracy of texture analysis (TA)–derived parameters combined with machine learning (ML) of non-contrast-enhanced T1w and T2w fat-saturated (fs) images with MR elastography (MRE) for ...
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Article
Endoscopic vacuum therapy (EVT) for early infradiaphragmal leakage after bariatric surgery—outcomes of six consecutive cases in a single institution
Anastomotic leakages or staple line defects after Roux-en-Y gastric bypass (RYGB) and primary laparoscopic sleeve gastrectomy (LSG), respectively, with consecutive bariatric revisional surgery are associated w...
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Article
Open AccessNo major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers
In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein exp...
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Article
Splenic duplication: a rare cause of acute upper gastrointestinal bleeding
Acute gastrointestinal bleeding represents a common medical emergency. We report the rare case of acute upper gastrointestinal bleeding caused by varices in the gastric fundus secondary to splenic duplication....
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Open AccessHyperferritinemia without iron overload in patients with bilateral cataracts: a case series
Hepatologists and internists often encounter patients with unexplained high serum ferritin concentration. After exclusion of hereditary hemochromatosis and hemosiderosis, rare disorders like hereditary hyperfe...
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Article
Open AccessMultiple infarcted regenerative nodules in liver cirrhosis after decompensation of cirrhosis: a case series
Liver cirrhosis is a common disease with many known complications. Cirrhosis represents a clinical spectrum, ranging from asymptomatic liver disease to hepatic decompensation. Manifestations of hepatic decompe...
