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  1. No Access

    Article

    A new function for the γ -tubulin ring complex as a microtubule minus-end cap

    Microtubule nucleation from centrosomes involves a lockwasher-shaped protein complex containing γ-tubulin, named the γ-tubulin ring complex (γTuRC). Here we investigate the mechanism by which the γTuRC nucleat...

    Christiane Wiese, Yixian Zheng in Nature Cell Biology (2000)

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    Article

    Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

    The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show th...

    Andrew Wilde, Sofia B. Lizarraga, Lijun Zhang, Christiane Wiese… in Nature Cell Biology (2001)

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    Article

    A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

    The activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) a...

    Ming-Ying Tsai, Christiane Wiese, Kan Cao, Ona Martin, Peter Donovan… in Nature Cell Biology (2003)