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Article
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
The activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) a...
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Article
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show th...
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Article
A new function for the γ -tubulin ring complex as a microtubule minus-end cap
Microtubule nucleation from centrosomes involves a lockwasher-shaped protein complex containing γ-tubulin, named the γ-tubulin ring complex (γTuRC). Here we investigate the mechanism by which the γTuRC nucleat...