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Article
Open AccessDynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro
Proteins adsorbing at nanoparticles have been proposed as critical toxicity mediators and are included in ongoing efforts to develop predictive tools for safety assessment. Strongly attached proteins can be is...
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Nanotoxicology and Regulatory Affairs
Like other parts of the nanotechnology revolution nanomedicines hold great promise and in the case of nanomedicines the potential for more efficient therapies. Engineered nanomaterials that are used as nanomed...
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Pumpspeicherkraftwerke
Photovoltaik und Windenergie haben in Deutschland einen immensen Boom erlebt. Da erneuerbare Energien aber Einspeisevorrang genießen, verringern sie die Einsatzdauern anderer Energieträger. Dadurch sinken die ...
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Article
Open AccessIdentification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line
The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology.
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Article
Optimizing the transient transfection process of HEK-293 suspension cells for protein production by nucleotide ratio monitoring
Large scale, transient gene expression (TGE) is highly dependent of the physiological status of a cell line. Therefore, intracellular nucleotide pools and ratios were used for identifying and monitoring the op...
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Article
Open AccessCaveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production
Retroviral Gag determines virus assembly at the plasma membrane and the formation of virus-like particles in intracellular multivesicular bodies. Thereby, retroviruses exploit by interaction with cellular part...
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Article
Open AccessAmphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts
We have recently shown that amphotropic murine leukemia virus (A-MLV) can enter the mouse fibroblast cell line NIH3T3 via caveola-dependent endocytosis. But due to the size and omega-like shape of caveolae it ...
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Article
Open AccessAmphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains
Cholesterol-rich microdomains like lipid rafts were recently identified as regions within the plasma membrane, which play an important role in the assembly and budding of different viruses, e.g., measles virus...
