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Article
Open AccessSelective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial
For well-defined deep (> 2/3 dentin extension) carious lesions, selective (SE) or stepwise (SW) carious tissue removals have been recommended, while there is limited comparative evidence for both. We compared ...
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Article
Schrittweise versus selektive Exkavation tiefer Milchmolarenkaries: 18-Monats-Ergebnisse einer randomisiert-kontrollierten Studie
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Article
Open AccessOral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature
Hereditary sensory and autonomic neuropathy type VIII is a rare autosomal recessive inherited disorder. Chen et al. recently identified the causative gene and characterized biallelic mutations in the PR domain-co...
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Article
Correction: Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception
Nat. Genet. 47 803–808 (2015); published online 25 May 2015; corrected after print 8 July 2015 In the version of this article initially published, there was an error with the affiliations for author Roman Chra...
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Article
Transcriptional regulator PRDM12 is essential for human pain perception
Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and part...
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Article
Open AccessSelective or stepwise removal of deep caries in deciduous molars: study protocol for a randomized controlled trial
For treating deep caries lesions, selective or stepwise (one- and two-step) incomplete excavation seems advantageous compared with complete caries removal. However, current evidence regarding the success, as d...
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Conductance-Based Models for the Evaluation of Brain Functions, Disorders, and Drug Effects
Neurological and psychiatric disorders such as Parkinson’s disease and clinical depression are diseases of the nervous system. Disorders of different autonomic functions, including disturbances of sleep, energ...
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Article
Open AccessThe role of intrinsic dynamics and noise for neural encoding and synchronization
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Article
Dental Findings in Patients with Ectodermal Dysplasia
Ectodermal dysplasia is an inherited disease caus ing malformations of all tissues originating from the ectoderm. The significance of this disease lies in severe hypodontia, and an accompanying hypoplasia of t...
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Article
Wertigkeit der zahnärztlichen Behandlung bei der interdisziplinären Betreuung eines Kindes mit Epidermolysis bullosa dystrophica hereditaria (Hallopeau-Siemens)
Die schwere Verlaufsform der hereditären Epidermolysis bullosa dystrophica mit Schleimhautbefall führt im allgemeinen zu Gebißzerstörung und eingeschränkter Nahrungsaufnahme. In der Folge kommt e...
