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Article
Open AccessTobacco use, self-reported professional dental cleaning habits, and lung adenocarcinoma diagnosis are associated with bronchial and lung microbiome alpha diversity
The lung microbiome is an inflammatory stimulus whose role in the development of lung malignancies is incompletely understood. We hypothesized that the lung microbiome associates with multiple clinical factors...
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Article
Open AccessBilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study
Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in ...
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Article
Open AccessPneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV
Chronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide and HIV is an independent risk factor for the development of COPD. However, the etiology of this increased risk and m...
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Article
Open AccessImpact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort
Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency roo...
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Biomarkers in Obstructive Airway Diseases
Asthma and chronic obstructive pulmonary disease (COPD) represent the two most common obstructive lung diseases worldwide, imparting a significant global public health burden. Both are now recognized as umbrel...
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Article
Open AccessChronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study
Chronic obstructive pulmonary disease (COPD) frequent exacerbators (FE) suffer increased morbidity and mortality compared to infrequent exacerbators (IE). The association between the oral and sputum microbiota...
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Article
Open AccessThe lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease
Oral taxa are often found in the chronic obstructive pulmonary disease (COPD) lung microbiota, but it is not clear if this is due to a physiologic process such as aspiration or experimental contamination at th...
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Article
Open AccessBiomarkers of inflammation in infants with cystic fibrosis
There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our obje...
