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Article
Open AccessCausal associations between gut microbiota and chronic prostatitis/chronic pelvic pain syndrome: a two-sample Mendelian randomization study
Recent researches have increasingly indicated a strong correlation between the gut microbiota and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Nevertheless, the impact of gut microbiota on CP/CP...
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Article
Open AccessSingle-cell transcriptome atlas of testes from mice with high-fat diets
Obesity is accompanied by multiple known health risks and increased morbidity, and obese men display reduced reproductive health. However, the impact of obesity on the testes at the molecular levels remain ina...
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Article
Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism
Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA...
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Article
Open AccessAssociation of genetic variants related to combined lipid-lowering and antihypertensive therapies with risk of cardiovascular disease: 2 × 2 factorial Mendelian randomization analyses
Lipid-lowering drugs and antihypertensive drugs are commonly combined for cardiovascular disease (CVD). However, the relationship of combined medications with CVD remains controversial. We aimed to explore the...
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Article
Open AccessPrognosis and immunological characteristics of HDAC family in pan-cancer through integrative multi-omic analysis
The histone deacetylase (HDAC) family plays a significant role in a variety of biological processes related to cancer, such as metabolism and cancer progression, and recognized as a target of anti-cancer drugs...
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Chapter and Conference Paper
Numerical Investigation of Sidewall Interference Control on Large Thickness Wind Turbine Airfoil
Sidewall interference control is very important to ensure the accuracy of large thickness airfoil wind tunnel experimental data. In this paper, a new idea of arranging tandem vortex generators (VG) at the junc...
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Chapter and Conference Paper
Experimental Study of Sidewall Interference Control on Large Thickness Airfoil
High-performance large-thickness airfoils with blunt trailing edge are important for the development of multi-megawatt large-scale wind turbines. Currently, serious sidewall interference problems are encounter...
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Article
Faster-FIIS-GMS: a novel object detection framework for instance search
Visual sensors are widely deployed in many promising detection fields, such as precision measurement, visual object detection and search. Instance search is a special object search method based on visual senso...
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Article
Open AccessConstruction and validation of a metabolism-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer
Tumor Metabolism is strongly correlated with prognosis. Nevertheless, the prognostic and therapeutic value of metabolic-associated genes in BCa patients has not been fully elucidated. First, in this study, met...
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Article
Open AccessPrevalence and characteristics of pain in moderate-to-severe obstructive sleep apnea patients and effect of CPAP treatment
Pain problems are common in patients with obstructive sleep apnea (OSA), but few studies have thoroughly evaluated pain in these patients. The objective of this study was to examine the prevalence and characte...
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Article
Open AccessRAB10 promotes breast cancer proliferation migration and invasion predicting a poor prognosis for breast cancer
RAB10, a member of the small GTPase family, has complex biological functions, but its role in breast cancer (BC) remains unclear. The aim of this study was to investigate the relationship between RAB10's role ...
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Article
Open AccessCorrection : HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case–control study and a prospective nested case–control study
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Article
Open AccessResearch on liver cancer segmentation method based on PCNN image processing and SE-ResUnet
As one of the malignant tumors with high mortality, the initial symptoms of liver cancer are not obvious. In addition, the liver is the largest internal organ of the human body, and its structure and distribut...
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Article
Open AccessCorrection: Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study
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Article
CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway
Circular RNAs (circRNAs) serve as novel noncoding RNAs that have crucial functions in the development of tumors, including those from bladder cancer (BCa). However, the role and underlying molecular mechanism ...
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Article
Open AccessHypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease
Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention. Altered methylation of ATP-binding cassette subfamily G member...
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Article
Open AccessInteractive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study
Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of CVD are scarce. This study aimed to assess the...
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Article
Open AccessBiomarkers selection and mathematical modeling in biological age estimation
Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated in years using mathematical mod...
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Article
Integrating polygenic and clinical risks to improve stroke risk stratification in prospective Chinese cohorts
The utility of the polygenic risk score (PRS) to identify individuals at higher risk of stroke beyond clinical risk remains unclear, and we clarified this using Chinese population-based prospective cohorts. Co...
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Article
Pan-cancer evidence of prognosis, immune infiltration, and immunotherapy efficacy for annexin family using multi-omics data
The annexin superfamily (ANXA) is made up of 12 calcium (Ca2+) and phospholipid binding protein members that have a high structural homology and play a key function in cancer cells. However, little research has b...
