-
Article
Open AccessWhite matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis
Subjective cognitive decline (SCD) is an early stage of dementia linked to Alzheimer's disease pathology. White matter changes were found in SCD using diffusion tensor imaging, but there are known limitations ...
-
Article
Open AccessVascular risk factors and astrocytic marker for the glymphatic system activity
Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is a...
-
Article
Open AccessStructure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia
Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread impairment of structural and functional integration has been demonstrated in schizophrenia. Although white matter (WM) microst...
-
Article
Open AccessThe phase of plasticity-induced neurochemical changes of high-frequency repetitive transcranial magnetic stimulation are different from visual perceptual learning
Numerous studies have found that repetitive transcranial magnetic stimulation (rTMS) modulates plasticity. rTMS has often been used to change neural networks underlying learning, often under the assumption tha...
-
Article
Short-term Medication Effects on Brain Functional Activity and Network Architecture in First-Episode psychosis: a longitudinal fMRI study
The effect of antipsychotic medications is critical for the long-term outcome of symptoms and functions during first-episode psychosis (FEP). However, how brain functions respond to the antipsychotic treatment...
-
Article
Open AccessInvestigating brain aging trajectory deviations in different brain regions of individuals with schizophrenia using multimodal magnetic resonance imaging and brain-age prediction: a multicenter study
Although many studies on brain-age prediction in patients with schizophrenia have been reported recently, none has predicted brain age based on different neuroimaging modalities and different brain regions in ...
-
Article
Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia
Technical developments and improved access to neuroimaging techniques have brought us closer to understanding the neuropathological origins of schizophrenia. Using data-driven disease-progression modelling on ...
-
Article
Open AccessProgressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study
Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades. However, when and how these brain abnormalities occur and evolve rem...
-
Article
Open AccessPredicting aging trajectories of decline in brain volume, cortical thickness and fractional anisotropy in schizophrenia
Brain-age prediction is a novel approach to assessing deviated brain aging trajectories in different diseases. However, most studies have used an average brain age gap (BAG) of individuals with schizophrenia o...
-
Article
An extended Human Connectome Project multimodal parcellation atlas of the human cortex and subcortical areas
A modified and extended version, HCPex, is provided of the surface-based Human Connectome Project-MultiModal Parcellation atlas of human cortical areas (HCP-MMP v1.0, Glasser et al. 2016). The original atlas w...
-
Article
Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes
Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory and higher-order cognitive processing. Connectome studies have suggested a principal primary-to-transmodal gradient in ...
-
Article
Open AccessClinical and behavior characteristics of individuals who used ketamine
This study aims to depict and compare clinical characteristics and risk behavior among groups of individuals using ketamine, polydrugs or smoking cigarette. A total of 185 drug-using participants and 49 smoker...
-
Article
Open AccessSocial and emotion dimensional organizations in the abstract semantic space: the neuropsychological evidence
An essential aspect of human cognition is supported by a rich reservoir of abstract concepts without tangible external referents (e.g., “honor”, “relationship”, “direction”). While decades of research showed t...
-
Article
Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis
Reliable map** of system-level individual differences is a critical first step toward precision medicine for complex disorders such as schizophrenia. Disrupted structural covariance indicates a system-level ...
-
Article
Open AccessCerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic...
-
Article
Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder
Sertraline is one of the most commonly prescribed antidepressants. Major depressive disorder (MDD) is characterized by spontaneous thoughts that are laden with negative affect—a “malignant sadness”. Prior neur...
-
Article
Open AccessCorrection to: Adherence among HIV-positive injection drug users undergoing methadone treatment in Taiwan
An amendment to this paper has been published and can be accessed via the original article.
-
Article
Open AccessEffects of early ketamine exposure on cerebral gray matter volume and functional connectivity
Ketamine has been used for medical purposes, most typically as an anesthetic, and recent studies support its use in the treatment of depression. However, ketamine tends to be abused by adolescents and young ad...
-
Article
Open AccessAdherence among HIV-positive injection drug users undergoing methadone treatment in Taiwan
The study aims were to investigate adherence to methadone maintenance treatment (MMT) and to identify associated clinical factors in patients who inject drugs diagnosed with human immunodeficiency virus (HIV) ...
-
Article
Open AccessCorrelation of internal carotid artery diameter and carotid flow with asymmetry of the circle of Willis
The purpose of this study was to clarify the effect of asymmetric COW variants on carotid flow changes, and proposed an easy estimate of the representative carotid flow volume for accurate numerical simulation.
