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Article
Open AccessGlutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK
Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance. This study develops a compound, JMF4073, inhibiting thymidy...
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Article
Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan
Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.
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Article
The nematode-trap** fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors
The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys oligospora and other nematode-trap** fungi develop dedicated structures for nematode cap...
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Article
Open AccessA Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.
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Article
Open AccessUnderstanding and alleviating informal caregiver burden through the development and validation of a caregiver strain index-based model in Taiwan
Quantifying the informal caregiver burden is important for understanding the risk factors associated with caregiver overload and for evaluating the effectiveness of services provided in Long-term Care (LTC).
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Article
Open AccessDevelopment of a risk prediction model for radiation dermatitis following proton radiotherapy in head and neck cancer using ensemble machine learning
This study aims to develop an ensemble machine learning-based (EML-based) risk prediction model for radiation dermatitis (RD) in patients with head and neck cancer undergoing proton radiotherapy, with the goal...
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Article
Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
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Article
Patients undergoing liver resection for non-alcoholic fatty liver disease-related hepatocellular carcinoma and those for viral hepatitis-related hepatocellular carcinoma have similar survival outcomes
Numerous studies have compared outcomes of liver resection (LR) of patients with non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) to those of patients with non-NAFLD-related HCC...
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Article
Open AccessGenetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study
This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based...
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Article
Acoustic Vortex-Assisted Thrombolysis Treatment in a Pulmonary Embolism Model Using a Miniature Ultrasound Catheter
Pulmonary embolism (PE) occurs when a blood clot, usually from the deep veins of the legs, travels through the bloodstream and becomes lodged in one of the arteries of the lungs. This blockage can be life-thre...
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Article
Open AccessSARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
The aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may initiate cytokine cascades and correlate the clinical characteristics of...
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Article
Open AccessHigh-performance near-infrared OLEDs maximized at 925 nm and 1022 nm through interfacial energy transfer
Using a transfer printing technique, we imprint a layer of a designated near-infrared fluorescent dye BTP-eC9 onto a thin layer of Pt(II) complex, both of which are capable of self-assembly. Before integration...
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Article
Open AccessEfficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials
The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries. Functional constipation accounts for 95% of pediatric constipation, and the efficacy of pharmacotherapy is limited,...
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Article
Open AccessDiastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department
Given the scarcity of studies analyzing the clinical predictors of pediatric septic cases that would progress to septic shock, this study aimed to determine strong predictors for pediatric emergency department...
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Article
Commodity taxation principle, heterogeneous goods, and endogenous choice between price and quantity contracts
In the context of firms’ endogenous choice between price and quantity contracts, we show that when firms choose different strategic variables under the destination principle, the government of the quantity-ori...
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Article
Open AccessInfluence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study
Despite vaccines’ effectiveness in reducing COVID-19 infection rates and disease severity, their impact on critical patients presenting with acute respiratory failure is elusive. The aim of this study was to f...
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Article
Open AccessComparison of the 2022 world health organization classification and international consensus classification in myelodysplastic syndromes/neoplasms
In 2022, two novel classification systems for myelodysplastic syndromes/neoplasms (MDS) have been proposed: the International Consensus Classification (ICC) and the 2022 World Health Organization (WHO-2022) cl...
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Article
Open AccessRisk of sleep disorders in patients with pneumoconiosis: a retrospective cohort study
Pneumoconiosis is associated with pulmonary and cardiovascular diseases; however, the link between pneumoconiosis and sleep disorders is not well understood. This study aimed to investigate the connection betw...
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Article
Open AccessAn algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified ...
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Article
Prophylaxis for paediatric emergence delirium in desflurane-based anaesthesia: a network meta-analysis
The prevalence of postoperative emergence delirium in paediatric patients (pedED) following desflurane anaesthesia is considerably high at 50–80%. Although several pharmacological prophylactic strategies have ...
