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  1. Article

    Open Access

    White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma

    We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI) can be used to reflect the progression of chronic b...

    Lan-Wan Wang, Kuan-Hung Cho, Pi-Yu Chao, Li-Wei Kuo, Chia-Wen Chiang in Scientific Reports (2024)

  2. Article

    Open Access

    The interrelationships between neuronal viability, synaptic integrity, microglial responses, and amyloid-beta formation in an in vitro neurotrauma model

    The interrelationships between neuronal viability, synaptic integrity, and microglial responses remain in infancy. In dealing with the question, we induced a stretch injury to evaluate the mechanical effects o...

    Lan-Wan Wang, Hung-Jung Lin, Chien-Ming Chao, Mao-Tsun Lin in Scientific Reports (2022)

  3. Article

    Open Access

    The effect of additional antimicrobial therapy on the outcomes of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis

    The effect of additional antimicrobial agents on the clinical outcomes of patients with idiopathic pulmonary fibrosis (IPF) is unclear.

    Ching-Yi Chen, Chao-Hsien Chen, Cheng-Yi Wang, Chih-Cheng Lai in Respiratory Research (2021)

  4. Article

    Open Access

    Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

    The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be...

    Pei-Hsuan Lin, Kuan-Hua Huang, Yu-Feng Tian, Cheng-Hsien Lin in Scientific Reports (2021)

  5. Article

    Open Access

    Outcome of liver cirrhosis patients requiring prolonged mechanical ventilation

    Acute respiratory failure requiring mechanical ventilation is a major indicator of intensive care unit (ICU) admissions in cirrhotic patients and is an independent risk factor for ICU mortality. This retrospec...

    Chih-Cheng Lai, Kuei-Ling Tseng, Chung-Han Ho, Shyh-Ren Chiang in Scientific Reports (2020)

  6. Article

    Open Access

    Comparison of machine learning models for the prediction of mortality of patients with unplanned extubation in intensive care units

    Unplanned extubation (UE) can be associated with fatal outcome; however, an accurate model for predicting the mortality of UE patients in intensive care units (ICU) is lacking. Therefore, we aim to compare the...

    Meng Hsuen Hsieh, Meng Ju Hsieh, Chin-Ming Chen, Chia-Chang Hsieh in Scientific Reports (2018)

  7. Article

    Open Access

    Prognostic factors and outcomes of unplanned extubation

    This study investigated the prognostic factors and outcomes of unplanned extubation (UE) in patients in a medical center’s 6 intensive care units (ICUs) and calculated their mortality risk. We retrospectively ...

    Chien-Ming Chao, Mei-I. Sung, Kuo-Chen Cheng, Chih-Cheng Lai in Scientific Reports (2017)

  8. Article

    Open Access

    The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome

    We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this...

    Chih-Cheng Lai, Mei-I. Sung, Chung-Han Ho, Hsiao-Hua Liu in Scientific Reports (2017)

  9. Article

    Open Access

    Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α

    Tumor necrosis factor-alpha (TNF-α) is elevated early in injured brain after traumatic brain injury (TBI), in humans and in animals. Etanercept (a TNF-α antagonist with anti-inflammatory effects) attenuates TB...

    Chung-Ching Chio, Chin-Hong Chang, Che-Chuan Wang, Chong-Un Cheong in BMC Neuroscience (2013)

  10. Article

    Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats

    To assess the therapeutic effect of melatonin on heat-induced acute lung inflammation and injury in rats.

    Wen-shiann Wu, Ming-ting Chou, Chien-ming Chao in Acta Pharmacologica Sinica (2012)