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Article
Open AccessA phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation
Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberrant or co...
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Article
Open AccessThe role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair
During aging, perturbation of muscle progenitor cell (MPC) constituents leads to progressive loss of muscle mass and accumulation of adipose and fibrotic tissue. Mesenchymal stem cells (MSCs) give rise to adip...
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Article
Open AccessHeterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy
Duchenne muscular dystrophy (DMD) is a progressive muscle disease, characterized by mutations in the X-linked dystrophin, that has several therapeutic options but no curative treatment. Transplantation of musc...
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Article
Open AccessCXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment
White adipose tissue (WAT) overgrowth in obesity is linked with increased aggressiveness of certain cancers. Adipose stromal cells (ASCs) can become mobilized from WAT, recruited by tumours and promote cancer ...
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Article
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
Extensive reprogramming of cellular energy metabolism is a hallmark of cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show...
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Article
CSN6 drives carcinogenesis by positively regulating Myc stability
Cullin-RING ubiquitin ligases (CRLs) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitinati...
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Article
A peptide probe for targeted brown adipose tissue imaging
The presence of brown adipose tissue responsible for thermogenic energy dissipation has been revealed in adult humans and has high clinical importance. Owing to limitations of current methods for brown adipose...
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Adipose Tissue-Derived Progenitor Cells and Cancer
Obesity, a condition of white adipose tissue (WAT) overgrowth and perturbation of system metabolic homeostasis, is a significant risk factor for cancer mortality. The mechanisms underlying the obesity-cancer l...
