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    Article

    Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT

    Androgen receptor (AR) splice variant 7 (AR-V7) is capable to enter nucleus and activate downstream signaling without ligand. AR-V7 assists the tumor growth, cancer metastasis, cancer stemness, and the evolvem...

    Ying-Yu Kuo, Chieh Huo, Chia-Yang Li, Chih-Pin Chuu in Cancer Gene Therapy (2024)

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    Open Access

    Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

    Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determi...

    Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-** Lin in Cell Communication and Signaling (2019)