-
Article
Open AccessReal-time monitoring of replication errors’ fate reveals the origin and dynamics of spontaneous mutations
The efficiency of replication error repair is a critical factor governing the emergence of mutations. However, it has so far been impossible to study this efficiency at the level of individual cells and to inv...
-
Article
Open AccessMammalian cell growth characterisation by a non-invasive plate reader assay
Automated and non-invasive mammalian cell analysis is currently lagging behind due to a lack of methods suitable for a variety of cell lines and applications. Here, we report the development of a high throughp...
-
Article
Open AccessInitial cell density encodes proliferative potential in cancer cell populations
Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear...
-
Protocol
Kinetic Modelling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs
Non-coding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-...
