-
Article
Open AccessPrCRS: a prediction model of severe CRS in CAR-T therapy based on transfer learning
CAR-T cell therapy represents a novel approach for the treatment of hematologic malignancies and solid tumors. However, its implementation is accompanied by the emergence of potentially life-threatening advers...
-
Article
Open AccessA score-based method of immune status evaluation for healthy individuals with complete blood cell counts
With the COVID-19 outbreak, an increasing number of individuals are concerned about their health, particularly their immune status. However, as of now, there is no available algorithm that effectively assesses...
-
Article
Open AccessInvestigation of CRS-associated cytokines in CAR-T therapy with meta-GNN and pathway crosstalk
Chimeric antigen receptor T-cell (CAR-T) therapy is a new and efficient cellular immunotherapy. The therapy shows significant efficacy, but also has serious side effects, collectively known as cytokine release...
-
Article
Open AccessPrediction of functional microexons by transfer learning
Microexons are a particular kind of exon of less than 30 nucleotides in length. More than 60% of annotated human microexons were found to have high levels of sequence conservation, suggesting their potential f...
