3 Result(s)
within
Cheng-Jung Ho
Cell Biology
Stem Cells
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Article
Open AccessSevere cellular stress drives apoptosis through a dual control mechanism independently of p53
For past two decades, p53 has been claimed as the primary sensor initiating apoptosis. Under severe cellular stress, p53 transcriptional activity activates BH3-only proteins such as Bim, Puma, or Noxa to nulli...
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Article
Open AccessSevere cellular stress activates apoptosis independently of p53 in osteosarcoma
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Do...
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Article
Open AccessTranscription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress
We previously reported that p53-mediated apoptosis is determined by severity of DNA damage, not by the level of p53, in doxorubicin-treated prostate cancer cells. In addition to doxorubicin, our results here i...
