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Article
Open AccessSevere cellular stress drives apoptosis through a dual control mechanism independently of p53
For past two decades, p53 has been claimed as the primary sensor initiating apoptosis. Under severe cellular stress, p53 transcriptional activity activates BH3-only proteins such as Bim, Puma, or Noxa to nulli...
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Article
Open AccessSevere cellular stress activates apoptosis independently of p53 in osteosarcoma
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Do...
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Article
Open AccessTranscription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress
We previously reported that p53-mediated apoptosis is determined by severity of DNA damage, not by the level of p53, in doxorubicin-treated prostate cancer cells. In addition to doxorubicin, our results here i...
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Article
Successful treatment of a delayed presentation of a gunshot injury to the femoral neck in an elderly man: a case report
Gunshot wounds involving major joints can be lethal as a result of the disruption to major neurovascular tracts. We report on a high-energy ballistic injury resulting in a comminuted femoral neck fracture in a...
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Chapter and Conference Paper
Neural Network Method for Protein Structure Search Using Cell-Cell Adhesion
We propose a neural network method for three dimensional protein structure search that utilizes the link relationships among features. This method is an offline index-based method which builds indices for prot...
