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Article
Open AccessLoss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types...
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Article
Open AccessTwo-stage complex action recognition framework for real-time surveillance automatic violence detection
Violent action classification in community-based surveillance is a particularly challenging concept in itself. The ambiguity of violence as a complex action can lead to the misclassification of violence-relate...
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Article
Open AccessCGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
To investigate specific brain regions and neural circuits that are responsible for migraine chronification.
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Article
Open AccessInvolvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control
Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment are causally related to mood disorders. BLM-s (BCL-2-like mole...
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Article
Open AccessAssessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons
Alzheimer’s disease (AD) is the most common type of dementia and also one of the leading causes of death worldwide. However, the underlying mechanisms remain unclear, and currently there is no drug treatment t...
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Chapter
Physiological Properties of Hippocampal Neurons
Neurons are the basic computational units of the nervous system. Information processing in the brain is critically dependent on the electrophysiological properties of individual neurons, which are determined b...
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Article
Gas-assisted microstructure elastic multiform UV imprint replication molding technology
This study developed an innovative gas-assisted microstructure elastic multiform UV imprint replication molding technology. It first designed and fabricated the upper closed gas chamber and lower four-directio...
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Article
Open AccessCausal Evidence for the Role of Specific GABAergic Interneuron Types in Entorhinal Recruitment of Dentate Granule Cells
The dentate gyrus (DG) is the primary gate of the hippocampus and controls information flow from the cortex to the hippocampus proper. To maintain normal function, granule cells (GCs), the principal neurons in...
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Article
Open AccessGain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease
Stem cell-based therapy is a potential treatment for neurodegenerative diseases, but its application to Alzheimer’s disease (AD) remains limited. Brain-derived neurotrophic factor (BDNF) is critical in the pat...
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Article
Open AccessType VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning
The calcium-sensitive type VI adenylyl cyclase (AC6) is a membrane-bound adenylyl cyclase (AC) that converts ATP to cAMP under stimulation. It is a calcium-inhibited AC and integrates negative inputs from Ca2+ an...
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Article
G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca2+ Accumulation
Early-onset familial Alzheimer’s disease (AD) is most commonly associated with the mutations in presenilin-1 (PS1). PS1 is the catalytic component of the γ-secretase complex, which cleaves amyloid precursor pr...
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Article
Open AccessASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory
Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potent...
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Article
TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1
Impairment of learning and memory is a significant pathological feature of many neurodegenerative diseases including FTLD-TDP. Appropriate regulation and fine tuning of spinogenesis of the dendrites, which is ...
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Chapter and Conference Paper
Vehicle Counting without Background Modeling
In general, the vision-based methods may face the problems of serious illumination variation, shadows, or swaying trees. Here, we propose a novel vehicle detection method without background modeling to overcom...
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Chapter and Conference Paper
A Fast Macroblock Mode Decision Algorithm for the Baseline Profile in the H.264 Video Coding Standard
A fast macroblock (MB) mode decision algorithm is proposed to reduce the computational complexity of H.264 video coding. First, a SKIP mode detection algorithm is developed to detect as many ”skipped” MB as po...
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Article
Visual stimuli–induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
Local GABA (γ-aminobutyric acid) circuits contribute to sensory experience–dependent refinement of neuronal connections in the develo** nervous system, but whether GABAergic synapses themselves can be rapidl...
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Article
A scalable model-based hand posture analysis system
Model-based hand posture analysis systems fall into two categories: hand without markers and hand with markers methods. The hand model fitting method proposed in this paper belongs to the second category. Howe...
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Article
The model-based dynamic hand posture identification using genetic algorithm
This paper proposes a new hand posture identification system which applies genetic algorithm to develop an efficient 3D hand-model-fitting method. The 3D hand-model-fitting method consists of (1) finding the ...
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Chapter and Conference Paper
The model-based dynamic hand posture identification using genetic algorithm
This paper proposes a genetic-based hand posture identification system which consists of an efficient model fitting method and a labeling technique. The model fitting method consists of (1) finding the closed ...
