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  1. Article

    Open Access

    Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems

    Microelectronic devices can directly communicate with biology, as electronic information can be transmitted via redox reactions within biological systems. By engineering biology’s native redox networks, we ena...

    Sally Wang, Chen-Yu Chen, John R. Rzasa, Chen-Yu Tsao, **yang Li in Nature Communications (2023)

  2. Article

    Open Access

    Parsed synthesis of pyocyanin via co-culture enables context-dependent intercellular redox communication

    Microbial co-cultures and consortia are of interest in cell-based molecular production and even as “smart” therapeutics in that one can take advantage of division of labor and specialization to expand both the...

    Kayla Chun, Kristina Stephens, Sally Wang, Chen-Yu Tsao in Microbial Cell Factories (2021)

  3. No Access

    Article

    Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals

    We developed a bioelectronic communication system that is enabled by a redox signal transduction modality to exchange information between a living cell-embedded bioelectronics interface and an engineered micro...

    Jessica L. Terrell, Tanya Tschirhart, Justin P. Jahnke in Nature Nanotechnology (2021)

  4. Article

    Open Access

    Bacterial co-culture with cell signaling translator and growth controller modules for autonomously regulated culture composition

    Synthetic biology and metabolic engineering have expanded the possibilities for engineered cell-based systems. The addition of non-native biosynthetic and regulatory components can, however, overburden the rep...

    Kristina Stephens, Maria Pozo, Chen-Yu Tsao, Pricila Hauk in Nature Communications (2019)

  5. Article

    Open Access

    Nano-guided cell networks as conveyors of molecular communication

    Advances in nanotechnology have provided unprecedented physical means to sample molecular space. Living cells provide additional capability in that they identify molecules within complex environments and actua...

    Jessica L. Terrell, Hsuan-Chen Wu, Chen-Yu Tsao, Nathan B. Barber in Nature Communications (2015)