5 Result(s)
within
Chen-Chang Lee
Biomedicine
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Article
Open AccessABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease
Since both APOE and ABCA7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we ...
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Article
MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer’s Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance
Functional polymorphisms in the promoter region of the monoamine oxidase A (MAOA) gene are associated with brain MAOA activity and transcriptional efficiency in patients with Alzheimer’s disease (AD). This study ...
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Article
Open AccessCatechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer’s Disease
The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigate...
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Article
Open AccessAssociations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease
Alzheimer’s disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemi...
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Article
Open AccessGenetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease
Inflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 bet...
