216 Result(s)
within
Chen**g Zhu
Life Sciences
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Article
Open AccessCaspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation
Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and tumorigenesis. However, the mechanism of non-apoptotic action...
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Article
Open AccessCrosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis
The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism of the crosstalk between cells in the pathogen...
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Article
Open AccessArbuscular mycorrhizal fungi by inducing watermelon roots secretion phthalates, altering soil enzyme activity and bacterial community composition to alleviate the watermelon wilt
Long-term continuous crop** has resulted in the frequent occurrence of fusarium wilt of watermelon (Citrullus lanatus). AMF inoculation can alleviate the continuous crop** barrier and reduce the incidence of ...
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Article
Open AccessRANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer
TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...
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Article
Open AccessTMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...
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Article
Correction: Roles of estrogen receptors during sexual reversal in pelodiscus sinensis
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Roles of estrogen receptors during sexual reversal in Pelodiscus sinensis
The Chinese soft-shelled turtle, Pelodiscus sinensis, exhibits distinct sexual dimorphism, with the males growing faster and larger than the females. During breeding, all-male offspring can be obtained using 17β-...
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Article
Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A2 receptors
The adenosine subfamily G protein-coupled receptors A2AR and A2BR have been identified as promising cancer immunotherapy candidates. One of the A2AR/A2BR dual antagonists, AB928, has progressed to a phase II clin...
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The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biological implications. In this study, our objective is to determine whether m6A modification c...
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Article
Relative importance of altitude shifts with plant and microbial diversity to soil multifunctionality in grasslands of north-western China
Above- and belowground biodiversity determines the capacity of ecosystems to provide multiple functions simultaneously (i.e., multifunctionality), while their relative importance along environmental gradients ...
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Article
Bacterial communities in cropland soils: Taxonomy and functions
Understanding microbial compositions and functions in arable soils is crucial for effective agroecosystem management. While many studies have explored this topic, large-scale investigations are lacking, result...
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The effects of phosphate application in Pb-contaminated soil on the oxidative stress of leaves, Pb accumulation in maize biomass and Pb speciation in rhizosphere soil
Reducing the bioavailability of lead (Pb) in soil is the key to alleviating the toxicity of Pb to plants. The present study investigated the effects of phosphorus application on Pb speciation in soil and the o...
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Article
Chemosensory detection of glucosinolates as token stimuli for specialist insects on brassicaceous plants: discovery and impact
In this paper, we take a historical perspective by going back to Verschaffelt’s landmark study published in 1910, in which he found that glucosinolates were used as token stimuli by larvae of Pieris butterflies, ...
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Article
New dawn of ginsenosides: regulating gut microbiota to treat metabolic syndrome
Metabolic Syndrome (MS) is an amalgamation of symptoms encompassing insulin resistance, obesity, dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. Emerging evidence suggests that the ...
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Article
Open AccessHNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy
Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...
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Article
Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq
Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications to DNA regulate gene expression in a cell-type-specific manner and are associated with various biological processes, but the two ...
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Article
Identification of an adult attractant for Anomala corpulenta by the reverse chemical ecology approach
Semiochemicals are dominant cues for insects to locate food, mates, predators, and oviposition sites. In the modern genomic era, semiochemicals have been identified not only by the conventional chemical ecolog...
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Article
Engineering the Tat-secretion pathway of Bacillus licheniformis for the secretion of cytoplasmic enzyme arginase
The industrial bacterium Bacillus licheniformis has long been used as a microbial factory for the production of enzymes due to its ability to secrete copious amounts of native extracellular proteins and its gener...
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Genome analysis of vB_SupP_AX, a novel N4-like phage infecting Sulfitobacter
Sulfitobacter is a bacterium recognized for its production of AMP-independent sulfite oxidase, which is instrumental in the creation of sulfite biosensors. This capability underscores its ecological and economic ...
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Small RNA and DNA Methylation of Tea Plants
Small RNAs are a category of short noncoding RNAs (ncRNAs) with 18–30 nt lengths. Based on their function and mechanisms of biogenesis, these small RNAs be classified into three major classes—microRNAs (miRNAs...
