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Article
Open AccessCirculating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma
While high circulating tumor DNA (ctDNA) levels are associated with poor survival for multiple cancers, variant-specific differences in the association of ctDNA levels and survival have not been examined. Here...
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Article
Integrated Capecitabine–Temozolomide with Radioembolization for Liver-Dominant G2 NETs: Long-Term Outcomes of a Single-Institution Retrospective Study
Capecitabine–Temozolomide (CapTem) is an oral chemotherapy regimen for NETs. Both drugs are radiosensitizers. Integrating CapTem and Y90 transarterial radioembolization (TARE) in patients with grade 2 neuroend...
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Article
Open AccessPhase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors
Indoleamine 2,3-dioxygenase 1 (IDO1), an interferon-inducible enzyme, contributes to tumor immune intolerance. Immune checkpoint inhibition may increase interferon levels; combining IDO1 inhibition with immune...
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Article
Open AccessA Novel EEG Based Spectral Analysis of Persistent Brain Function Alteration in Athletes with Concussion History
The neurocognitive sequelae of a sport-related concussion and its management are poorly defined. Detecting deficits are vital in making a decision about the treatment plan as it can persist one year or more fo...
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Article
Open AccessBiogenesis of protein bodies during vicilin accumulation in Medicago truncatula immature seeds
Grain legumes play a worldwide role as a source of plant proteins for feed and food. In the model legume Medicago truncatula, the organisation of protein storage vacuoles (PSV) in maturing seeds remains unknown.
