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Article
Open AccessLABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA
Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...
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Article
Open AccessA comprehensive approach to lifestyle intervention based on a calorie-restricted diet ameliorates liver fat in overweight/obese patients with NAFLD: a multicenter randomized controlled trial in China
Nonalcoholic fatty liver disease (NAFLD) is a globally increasing health epidemic. Lifestyle intervention is recommended as the main therapy for NAFLD. However, the optimal approach is still unclear. This stud...
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Chapter and Conference Paper
Beyond Universal Transformer: Block Reusing with Adaptor in Transformer for Automatic Speech Recognition
Recently, Transformer-based models have excelled in end-to-end (E2E) automatic speech recognition (ASR), enabling deployment on smart devices. However, their large parameter requirements pose challenges for AS...
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Chapter and Conference Paper
HiFi-WaveGAN: Generative Adversarial Network with Auxiliary Spectrogram-Phase Loss for High-Fidelity Singing Voice Generation
Entertainment-oriented singing voice synthesis (SVS) requires a vocoder to generate high-fidelity (e.g. 48 kHz) audio. However, most text-to-speech (TTS) vocoders cannot reconstruct the waveform well in this s...
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Article
Open AccessDissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular het...
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Reference Work Entry In depth
Epigenetics and 5-Hydroxymethylcytosines as a Biomarker in Type 2 Diabetes
Type 2 diabetes (T2D) is a lifelong chronic condition that impairs the body’s normal function of regulating and using sugar (glucose) for energy. Continuous high blood sugar levels will eventually damage vital...
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Article
Open AccessCharacterization of the Illumina EPIC array for optimal applications in epigenetic research targeting diverse human populations
The Illumina EPIC array is widely used for high-throughput profiling of DNA cytosine modifications in human samples, covering more than 850,000 modification sites across various genomic features. The applicati...
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Article
The Microbiota–Gut–Brain Axis and Epilepsy
Honoured as the second genome in humans, the gut microbiota is involved in a constellation of physiological and pathological processes, including those related to the central nervous system. The communication ...
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Article
Applications of nanomaterials in COVID-19 pandemic
The novel coronavirus 2019 (COVID-19) pandemic represents one of the biggest global health threats in the last two decades, so researchers around the world are searching for solutions and treatments for COVID-...
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Living Reference Work Entry In depth
Epigenetics and 5-Hydroxymethylcytosines as a Biomarker in Type 2 Diabetes
Type 2 diabetes (T2D) is a lifelong chronic condition that impairs the body’s normal function of regulating and using sugar (glucose) for energy. Continuous high blood sugar levels will eventually damage vital...
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Article
Open AccessAlterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma
The 5-methylcytosines (5mC) have been implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). However, the role of 5-hydroxymethylcytosines (5hmC) that are generat...
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Article
Open AccessTowards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy
Robust and clinically convenient biomarkers for cancer diagnosis, early detection, and prognosis have great potential to improve patient survival and are the key to precision medicine. The advent of next-gener...
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Article
The Expression Alteration of BC1 RNA and its Interaction with Eukaryotic Translation Initiation Factor eIF4A Post-Status Epilepticus
Abnormal dendritic sprouting and synaptic remodelling are important pathological features of temporal lobe epilepsy. BC1 RNA is a translation repressor involved in the regulation of the dendritic protein synth...
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Article
CCL17 combined with CCL19 as a nasal adjuvant enhances the immunogenicity of an anti-caries DNA vaccine in rodents
CCL19 and its receptor CCR7 are essential molecules for facilitating the trafficking of mature dendritic cells (DCs) and hel** to establish a microenvironment in lymphoid tissues to initiate primary immune r...
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Article
TRPC Channels: Prominent Candidates of Underlying Mechanism in Neuropsychiatric Diseases
Alterations in intracellular Ca2+ concentration ([Ca2+]i) play a crucial role in fundamental cellular events from transcriptional regulation to migration and proliferation. The transient receptor potential (TRP) ...
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Article
Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is the most common form of intractable epilepsy and is always accompanied with hippocampal sclerosis. The molecular mechanism of this pathological phenomenon has been extensively e...
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Article
Characteristics of InGaN-based superluminescent diodes with one-sided oblique cavity facet
We have fabricated InGaN-based superluminescent diodes (SLDs) with one-sided oblique facet. The characteristics of the SLDs and laser diodes with the same cavity length (800 μm) were compared. The typical peak...
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Article
Intranasal co-delivery of IL-6 gene enhances the immunogenicity of anti-caries DNA vaccine
To investigate the effects of co-delivering IL-6 expressing plasmid pCI-IL-6 on the immunogenicity of the anti-caries DNA vaccine pCIA-P, which encodes the surface protein antigen PAc of Streptococcus mutans.
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Article
Optimization of the cavity facet coating in high power GaN-based semiconductor laser diodes
A method to calculate the reflectivity of the coated cavity facet was proposed, and the distribution of the optical power near the two coated cavity facets was calculated for GaN-based laser diodes. A new desi...
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Article
Structure and Process Parameter Optimization for Sub-10nm Gate Length Fully Depleted N-Type SOI MOSFETs by TCAD Modeling and Simulation
According to most recent 2004 International Technology Roadmap for Semiconductor (2004 ITRS), the high performance (HP) MOSFET physical gate length will be scaled to 9nm (22nm technology node) in 2016. We inve...
