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Article
Open AccessANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function
Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum disorder (ASD), attention deficit/hyperactivity disorder, and spe...
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Article
Effects of Sevoflurane Exposure on Fetal Brain Development Using Cerebral Organoids
Sevoflurane is a safe and well-known inhaled anesthetic. Given that sevoflurane can be delivered to develo** fetuses through the mother, it is critical to determine whether this agent affects fetal neurodeve...
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Article
Open AccessHaploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome
Neurodevelopmental disorders, including autism spectrum disorder, have complex polygenic etiologies. Single-gene mutations in patients can help define genetic factors and molecular mechanisms underlying neurod...
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Article
Open AccessTWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells
Two-pore domain K+ (K2P) channels have been shown to modulate neuronal excitability. The physiological role of TWIK-1, the first identified K2P channel, in neuronal cells is largely unknown, and we reported previ...
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Article
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice
The functional role of genetic variants in glia in the pathogenesis of psychiatric disorders remains poorly studied. Disrupted-In-Schizophrenia 1 (DISC1), a genetic risk factor implicated in major mental disor...
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Article
Open AccessSuppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells
Anoctamin-1 (ANO1) acts as a Ca2+-activated Cl− channel in various normal tissues, and its expression is increased in several different types of cancer. Therefore, understanding the regulation of ANO1 surface exp...
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Article
Open AccessTWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus
Two-pore domain K+ (K2P) channels have been shown to modulate neuronal excitability. However, physiological function of TWIK-1, the first identified member of the mammalian K2P channel family, in neuronal cells i...
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Article
Open AccessDepletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) Channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death
TRPM4 channels are Ca2+-activated nonselective cation channels which are deeply involved in physiological and pathological conditions. However, their trafficking mechanism and binding partners are still elusive.
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Article
Open AccessSignificant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
The pathogenesis of osteonecrosis of the femoral head (ONFH) has been implicated in hypofibrinolysis and blood supply interruption. Previous studies have demonstrated that decreased fibrinolytic activity due t...
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Article
Open AccessFrontier of Epilepsy Research - mTOR signaling pathway
Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability. Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades a...
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Article
Open AccessTelomerase is strongly activated in hepatocellular carcinoma but not in chronic hepatitis and cirrhosis
Telomerase is highly activated in human immortal cell lines and tumor tissues, whereas it is not activated in primary cell strains and many tumor-adjacent tissues. It is suggested that telomerase activation is...
