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  1. Article

    Open Access

    Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

    Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. ...

    Shu Xu, **aozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma… in BMC Medicine (2023)

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  2. Article

    Open Access

    Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression

    Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the re...

    Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, … in Nature Communications (2023)

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  3. No Access

    Article

    Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota

    The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor; however, their functional differences have remained obscure. Here we found that Il17f–/– mice resisted chemically induced c...

    Ce Tang, Shigeru Kakuta, Kenji Shimizu, Motohiko Kadoki… in Nature Immunology (2018)