12 Result(s)
within
Catherine M Hawrylowicz
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Article
Open AccessVitamin D3 regulates PM-driven primary human neutrophil inflammatory responses
Recent evidence has demonstrated that both acute and chronic exposure to particulate air pollution are risk factors for respiratory tract infections and increased mortality from sepsis. There is therefore an u...
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Article
ASTHMA — comparing the impact of vitamin D versus UVR on clinical and immune parameters
The incidence of asthma has increased markedly since the 1960s and is currently estimated to affect more than 300 million individuals worldwide. A number of environmental factors are implicated in asthma patho...
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Article
Open AccessInterleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei
Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is corr...
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Article
Open AccessDepigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3
Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisatio...
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Article
Open AccessActivin-A is up-regulated in severe asthma, attenuates allergic responses and is associated with angiogenesis
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Chapter
Vitamin D and Regulatory T Cells
Epidemiological studies highlight the rising prevalence of vitamin D deficiency and insufficiency and its association with poor respiratory health, including asthmatic disease. These and further studies have i...
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Article
Open AccessComprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functio...
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Article
The Impact of Vitamin D on Regulatory T Cells
Epidemiologic studies highlight the increasing prevalence of vitamin D deficiency and insufficiency and its association with an increased risk of autoimmune diseases and poor respiratory function, including as...
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Chapter
Dendritic Cells, Macrophages and Monocytes in Allergic Disease
Antigen-presenting cells (APC) are present throughout mucosal surfaces of the skin, gut and respiratory tract. Dendritic cells (DC), the principal APC, receive and translate environmental signals, which promot...
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Chapter
T Cells in Allergic Disease
The type I (CD4 + Th1, CD8 + Tc1) and type II (CD4 + Th2, CD8 + Tc2) paradigm of cytokine-secreting T cell subsets has advanced considerably in recent years. CD4 + Th2 cells have been closely associated with i...
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Article
Open AccessImmunological intervention in human diseases
A recent Keystone Symposium Meeting on "Immunological Intervention in Human Disease" was held in Big Sky, Montana on January, 6–11, 2007, organized by Jacques Banchereau, Federica Sallusto and Robert Coffman. ...
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Article
Human spleen cells mediating natural killing: Altered natural cytotoxicity of spleen effector cells from patients with carcinoma
Spleen cells from eight patients with abdominal carcinoma and six patients undergoing major surgery for a variety of disease entities were assayed for natural cytotoxicity towards 51Cr-labelled K 562 target cells...
