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Article
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells
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Article
Open AccessAuthor Correction: Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
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Article
Open AccessIdentification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms
A central challenge in develo** personalized cancer cell immunotherapy is the identification of tumor-reactive T cell receptors (TCRs). By exploiting the distinct transcriptomic profile of tumor-reactive T c...
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Article
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells
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Article
Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination
Multivalent presentation of ligands often enhances receptor activation and downstream signalling. DNA origami offers a precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanopar...
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Article
Open AccessIntegrative genoty** of cancer and immune phenotypes by long-read sequencing
Single-cell transcriptomics has become the definitive method for classifying cell types and states, and can be augmented with genotype information to improve cell lineage identification. Due to constraints of ...
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Article
Open AccessPublisher Correction: Slide-tags enables single-nucleus barcoding for multimodal spatial genomics
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Chapter and Conference Paper
DIISCO: A Bayesian Framework for Inferring Dynamic Intercellular Interactions from Time-Series Single-Cell Data
Characterizing cell-cell communication and tracking its variability over time is essential for understanding the coordination of biological processes mediating normal development, progression of disease, or re...
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Article
Open AccessSlide-tags enables single-nucleus barcoding for multimodal spatial genomics
Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex tissues are ...
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Article
Open AccessDictionary of immune responses to cytokines at single-cell resolution
Cytokines mediate cell–cell communication in the immune system and represent important therapeutic targets1–3. A myriad of studies have highlighted their central role in immune function4–13, yet we lack a global ...
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Article
Latent human herpesvirus 6 is reactivated in CAR T cells
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a ...
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Article
Author Correction: Massively parallel single-cell mitochondrial DNA genoty** and chromatin profiling
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Article
ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer
Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is treated with ALK tyrosine kinase inhibitors (TKIs), but the lack of activity of immune checkpoint inhibitors (ICIs) is poorly unde...
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Article
Dynamics and specificities of T cells in cancer immunotherapy
Recent advances in cancer immunotherapy — ranging from immune-checkpoint blockade therapy to adoptive cellular therapy and vaccines — have revolutionized cancer treatment paradigms, yet the variability in clin...
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Article
Open AccessEnhancing CAR-T cell functionality in a patient-specific manner
Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of st...
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Article
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome
Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we c...
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Article
Molecular map of chronic lymphocytic leukemia and its impact on outcome
Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymp...
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Article
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies. Approximately half of patients with refractory large B cell lymphomas achieve durable responses from...
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Article
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
Within the tumour microenvironment, CD4+ T cells can promote or suppress antitumour responses through the recognition of antigens presented by human leukocyte antigen (HLA) class II molecules1,2, but how cancers ...
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Article
Open AccesscyCombine allows for robust integration of single-cell cytometry datasets within and across technologies
Combining single-cell cytometry datasets increases the analytical flexibility and the statistical power of data analyses. However, in many cases the full potential of co-analyses is not reached due to technica...
