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Article
Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol
Cardiovascular disease (CVD) is a public health concern, and the third cause of death worldwide. Several epidemiological studies and experimental approaches have demonstrated that consumption of polyphenol-enr...
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Reference Work Entry In depth
ANT
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Chapter
Mitochondrial Regulation of Cell Death
Mitochondria are multifaceted organelles exerting vital as well as lethal functions within eukaryotic cells. When fueled with substrates and oxygen, mitochondria govern metabolic pathways, regulate calcium flu...
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Living Reference Work Entry In depth
ANT
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Protocol
Enzymatic Assays for Probing Mitochondrial Apoptosis
Isolated mitochondria are an invaluable analytical tool to probe mitochondrial function and evaluate apoptosis induction via the so-called mitochondrial pathway. Irrespective of their tissue origin (e.g., hear...
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Living Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
A high resistance and heterogeneous response to conventional anti-cancer chemotherapies characterize malignant cutaneous melanoma, the most aggressive and deadly form of skin cancer. Withaferin A (WFA), a with...
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice
Dengue viruses belong to the Flavivirus family and are responsible for hemorrhagic fever in Human. Dengue virus infection triggers apoptosis especially through the expression of the small membrane (M) protein....
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
Methods for the assessment of mitochondrial membrane permeabilization in apoptosis
Mitochondrial membrane permeabilization (MMP) is considered as the “point-of-no-return” in numerous models of programmed cell death. Indeed, mitochondria determine the intrinsic pathway of apoptosis, and play ...
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Article
Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria
The human probiotic Propionibacterium freudenreichii kills colorectal adenocarcinoma cells through apoptosis in vitro via its metabolites, the short chain fatty acids (SCFA), acetate and propionate. However, the ...
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Article
Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis
In the present study, the toxicity of yperite, SM, and its structural analogue mechlorethamine, HN2, was investigated in a human bronchial epithelial cell line 16HBE. Cell detachment was initiated by caspase-2...
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Article
Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
Mitochondria are potent integrators/coordinators of apoptosis signaling pathways. Indeed, under physiological conditions, the initiation of apoptosis leads to the accumulation of second messengers that converg...