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Article
Open AccessReplication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells
Transcription replication collisions (TRCs) constitute a major intrinsic source of genome instability but conclusive evidence for a causal role of TRCs in tumor initiation is missing. We discover that lack of ...
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Article
Open AccessInactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression
The NAD+-dependent SIRT1-7 family of protein deacetylases plays a vital role in various molecular pathways related to stress response, DNA repair, aging and metabolism. Increased activity of individual sirtuins o...
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Article
Open AccessNext-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples – a proof-of-principle assessment
The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive funga...
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Article
Open AccessPrmt5 is a regulator of muscle stem cell expansion in adult mice
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling t...
