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  1. No Access

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    Signal Processing and the Design of Microarray Time-Series Experiments

    Recent findings of a genome-wide oscillation involving the transcriptome of the budding yeast Saccharomyces cerevisiae suggest that the most promising path to an understanding of the cell as a dynamic system will...

    Robert R. Klevecz, Caroline M. Li, James L. Bolen in Microarray Data Analysis (2007)

  2. No Access

    Article

    Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases

    The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state. The iminorib...

    Caroline M. Li, Peter C. Tyler, Richard H. Furneaux… in Nature Structural Biology (1999)

  3. No Access

    Article

    The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

    The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 Å resolution. ImmucillinGP was designed as a stable analog with the stereoelectroni...

    Wuxian Shi, Caroline M. Li, Peter C. Tyler… in Nature Structural Biology (1999)