11 Result(s)
within
Caroline Junqueira
English
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Article
Publisher Correction: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
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Article
Open AccessASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombinant protein, encoded in plasmids or human adenovirus 5 (hAd5) confers robust protection a...
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Article
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Natural killer (NK) cells kill infected, transformed and stressed cells when an activating NK cell receptor is triggered1. Most NK cells and some innate lymphoid cells express the activating receptor NKp46, encod...
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Article
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
SARS-CoV-2 can cause acute respiratory distress and death in some patients1. Although severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers inflammation is not clear2. Monocytes and macro...
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Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for patholog...
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γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis
Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum–infected patients. Although previous studies suggested that γδ2 T cells help control erythro...
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Open AccessAuthor Correction: Caspase-8 mediates inflammation and disease in rodent malaria
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessCaspase-8 mediates inflammation and disease in rodent malaria
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of syst...
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearin...
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Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax–infected reticulocytes
Plasmodium vivax causes approximately 100 million clinical malaria cases yearly1,2. The basis of protective immunity is poorly understood and thought to be mediated by antibodies3,4. Cytotoxic CD8+ T cells protec...
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Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1
The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces bot...
