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Article
Open AccessIntegrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expressi...
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Article
Open AccessGWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer
Based on our initial genome-wide association study (GWAS) on esophageal squamous cell carcinoma (ESCC) in Han Chinese, we conducted a follow-up study to examine the single nucleotide polymorphisms (SNPs) assoc...
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Article
Open AccessIntegrative genomics analysis of genes with biallelic loss and its relation to the expression of mRNA and micro-RNA in esophageal squamous cell carcinoma
Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy num...
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Article
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...
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Article
Jasmine tea consumption and upper gastrointestinal cancer in China
Epidemiological data on green/jasmine tea and esophageal as well as gastric cancer are limited and inconclusive.
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Article
Open AccessBiomarkers of apoptosis and survival in esophageal squamous cell carcinoma
Cancer of the esophagus is a deadly malignancy, and development of biomarkers that predict survival is an urgent need. The apoptotic pathways have been hypothesized as important in progression of esophageal sq...
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Article
Open AccessFamily history of cancer and risk for esophageal and gastric cancer in Shanxi, China
Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.
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Article
Open AccessQuantitative real-time RT-PCR validation of differential mRNA expression of SPARC, FADD, Fascin, COL7A1, CK4, TGM3, ECM1, PPL and EVPLin esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors and typically presents at an advanced and rapidly fatal stage. To better understand the role of genetics in the etiology and preven...
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Article
Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer
Previous studies of esophageal squamous cell carcinoma (ESCC) have shown a high frequency of allelic loss on chromosome 13q, infrequent somatic mutations in BRCA2, and a suggested association between a positive f...
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Article
Feasibility of conducting a lung-cancer chemoprevention trial among tin miners in Yunnan, P. R. China
Tin miners in Yunnan Province in southern China have an extremely high rate of lung cancer, more than one percent per year among those at ‘high risk’ (40 + years old, with 10 + years of underground mining and/...
