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  1. No Access

    Article

    Targeting **st with compounds that disrupt RNA structure and X inactivation

    Although more than 98% of the human genome is non-coding1, nearly all of the drugs on the market target one of about 700 disease-related proteins. The historical reluctance to invest in non-coding RNA stems partl...

    Rodrigo Aguilar, Kerrie B. Spencer, Barry Kesner, Noreen F. Rizvi… in Nature (2022)

  2. Article

    Open Access

    Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin

    RCOR1 is a known transcription repressor that recruits and positions LSD1 and HDAC1/2 on chromatin to erase histone methylation and acetylation. However, there is currently an incomplete understanding of RCOR1...

    Carlos Rivera, Hun-Goo Lee, Anna Lappala, Danni Wang… in Nature Communications (2022)

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  3. Article

    Open Access

    OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers

    The pervasive role of microRNAs (miRNAs) in cancer pathobiology drives the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, meticulous screening...

    Paloma del C. Monroig-Bosque, Maitri Y. Shah, **ao Fu… in Scientific Reports (2018)

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