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  1. No Access

    Article

    Targeting **st with compounds that disrupt RNA structure and X inactivation

    Although more than 98% of the human genome is non-coding1, nearly all of the drugs on the market target one of about 700 disease-related proteins. The historical reluctance to invest in non-coding RNA stems partl...

    Rodrigo Aguilar, Kerrie B. Spencer, Barry Kesner, Noreen F. Rizvi… in Nature (2022)

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    Article

    Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation

    Although polycomb repressive complex 2 (PRC2) is now recognized as an RNA-binding complex, the full range of binding motifs and why PRC2–RNA complexes often associate with active genes have not been elucidated...

    Michael Rosenberg, Roy Blum, Barry Kesner… in Nature Structural & Molecular Biology (2021)

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    Article

    PAR-TERRA directs homologous sex chromosome pairing

    New analyses reveal that TERRA transcripts arising from the subtelomeric pseudoautosomal (PAR) region of sex chromosomes nucleate pairing of X alleles in mouse ES cells.

    Hsueh-** Chu, John E Froberg, Barry Kesner… in Nature Structural & Molecular Biology (2017)