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Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease

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  1. Article

    Open Access

    Designed active-site library reveals thousands of functional GFP variants

    Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantiall...

    Jonathan Yaacov Weinstein, Carlos Martí-Gómez… in Nature Communications (2023)

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  2. Article

    Open Access

    Specificity, synergy, and mechanisms of splice-modifying drugs

    Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models ...

    Yuma Ishigami, Mandy S. Wong, Carlos Martí-Gómez, Andalus Ayaz… in Nature Communications (2024)

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