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Living Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Article
Open AccessThree-dimensional vascular microenvironment landscape in human glioblastoma
The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this...
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Reference Work Entry In depth
MPTP: Advances from an Evergreen Neurotoxin
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) researc...
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Chapter and Conference Paper
Modulatory Role of NK1 Receptors in the Basal Ganglia. Studies in NK1-/- Mice
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Article
Parkinson's disease and inflammatory changes
In 1988 McGeer and colleagues (Neurology 38, 1285–91) observed an activation of the microglia in substantia nigrapars compacta (SNpc) and striatum of brains from patients with Parkinson's disease. In the years th...
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Article
Functional anatomy of thalamus and basal ganglia
Thalamus.The human thalamus is a nuclear complex located in the diencephalon and comprising of four parts (the hypothalamus, the epythalamus, the ventral thalamus, and the dorsal thalamus). The t...
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Chapter
Blood Vessels And Neurodegeneration In Parkinson’s Disease
Parkinson’s disease (PD) is characterised by a differential vulnerability of dopaminergic neurons in the mesencephalon. The loss is severe in the substantia nigra pars compacta (SNpc) (85-90%), intermediate in th...