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Article
Open AccessThree-dimensional vascular microenvironment landscape in human glioblastoma
The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this...
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Chapter
Increase of Secondary Processes of Microglial and Astroglial Cells After MPTP-Induced Degeneration in Substantia Nigra Pars Compacta of Non Human Primates
Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated w...
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Chapter
Inflammatory Response in Parkinsonism
Inflammatory responses have been proposed as important factors in dopaminergic neuro-degeneration in Parkinsonism. Increasing evidence suggests that the alteration of the glial microenvironment induced by neur...
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Chapter and Conference Paper
Modulatory Role of NK1 Receptors in the Basal Ganglia. Studies in NK1-/- Mice
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Article
Parkinson's disease and inflammatory changes
In 1988 McGeer and colleagues (Neurology 38, 1285–91) observed an activation of the microglia in substantia nigrapars compacta (SNpc) and striatum of brains from patients with Parkinson's disease. In the years th...
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Chapter
Blood Vessels And Neurodegeneration In Parkinson’s Disease
Parkinson’s disease (PD) is characterised by a differential vulnerability of dopaminergic neurons in the mesencephalon. The loss is severe in the substantia nigra pars compacta (SNpc) (85-90%), intermediate in th...