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Article
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have ...
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Article
Cell death in development, maintenance, and diseases of the nervous system
Cell death, be it of neurons or glial cells, marks the development of the nervous system. Albeit relatively less so than in tissues such as the gut, cell death is also a feature of nervous system homeostasis—e...
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Article
Open AccessManagement of cell death in parasitic infections
For a long time, host cell death during parasitic infection has been considered a reflection of tissue damage, and often associated with disease pathogenesis. However, during their evolution, protozoan and hel...
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Article
Open AccessLigand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages
Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engu...
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Article
Determining the effector response to cell death
Cell death occurs when a pathogen invades a host organism or the organism is subjected to sterile injury. Thus, cell death is often closely associated with the induction of an immune response. Furthermore, cel...
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Article
Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
A conserved dendritic-cell regulatory program limits antitumour immunity
Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control the response to checkpoint b...
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Article
Serous macrophages pack Bhlhe40 for a randonnée
The transcription factor Bhlhe40 is required for the homeostatic proliferation of peritoneal macrophages and their expansion during type 2 immunity.
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Article
Induction of sterile type 2 inflammation
Microparticle debris from prosthetic implants has been shown to induce a type 2 inflammatory response through a Bruton’s tyrosine kinase-dependent signalling pathway.
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Article
PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization
Polarity is a fundamental feature of cells. Protein complexes, including the PAR3–PAR6–aPKC complex, have conserved roles in establishing polarity across a number of eukaryotic cell types. In neurons, polarity...
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Article
TAM receptors regulate multiple features of microglial physiology
Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cell...
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Article
Immunobiology of the TAM receptors
The TAM receptor protein tyrosine kinases — TYRO3, AXL and MER — have important roles in the immune, nervous, reproductive and vascular systems. Two closely re...
