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  1. No Access

    Article

    Breast cancer quality control

    Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cel...

    Cam Patterson, Sarah Ronnebaum in Nature Cell Biology (2009)

  2. No Access

    Article

    Torturing a blood vessel

    Experiments in mice and zebrafish uncover a pathway behind malformed blood vessels in the brain (pages 169–176 & 177–184

    Cam Patterson in Nature Medicine (2009)

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    Chapter

    The Role of Thrombin in Vascular Development

    Vasculogenesis is essential for embryonic development. The vasculature and the intravascular blood compartment develop in a close spatial and temporal relationship. Here we discuss how thrombin, as the common ...

    Martin Moser, Cam Patterson* in Thrombin (2009)

  4. No Access

    Article

    The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

    To maintain quality control in cells, mechanisms distinguish among improperly folded peptides, mature and functional proteins, and proteins to be targeted for degradation. The molecular chaperones, including h...

    Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu… in Nature Cell Biology (2001)

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    Article

    The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

    The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient1,2,3,4. Most nascent CFTR is retained in th...

    Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger… in Nature Cell Biology (2001)

  6. No Access

    Article

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB (NF-κB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqui Han… in Molecular and Cellular Biochemistry (2000)