-
Article
Open AccessDevelopment and validation of a novel preoperative clinical model for predicting lymph node metastasis in perihilar cholangiocarcinoma
We aimed to develop a novel preoperative nomogram to predict lymph node metastasis (LNM) in perihilar cholangiocarcinoma (pCCA) patients.
-
Article
Open AccessImpact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans
A number of observational studies indicate that insomnia is linked to inflammatory digestive diseases (IDDs). However, the definite relationship between insomnia and IDDs remains unclear.
-
Article
Open AccessComprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model
Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components of the extracellular matrix. This function has increasingly been considered to play a major proteolys...
-
Article
Open AccessPancreatic adenocarcinoma associated immune-gene signature as a novo risk factor for clinical prognosis prediction in hepatocellular carcinoma
Pancreatic adenocarcinoma (PAAD) has high mortality and a very poor prognosis. Both surgery and chemotherapy have a suboptimal therapeutic effect, and this caused a need to find new approaches such as immunoth...
-
Article
Open AccessDevelopment of nomogram models of inflammatory markers based on clinical database to predict prognosis for hepatocellular carcinoma after surgical resection
Inflammation plays a significant role in tumour development, progression, and metastasis. In this study, we focused on comparing the predictive potential of inflammatory markers for overall survival (OS), recu...
-
Article
Open AccessCircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis
Hepatocellular carcinoma (HCC) predominantly occurs in patients with chronic liver disease, accounting for 70–90% of all liver cancer cases. The role of circFOXM1/miR-1179/SPAG5 axis in HCC has not been report...
-
Article
Open AccessTherapeutic effectiveness and safety of sintilimab-dominated triple therapy in unresectable hepatocellular carcinoma
Immune checkpoint inhibitor therapy has shown promising results in patients with unresectable hepatocellular carcinoma. This study aimed to evaluate the effectiveness and safety of sintilimab, a programmed cel...
-
Article
Open AccessAuthor Correction: Preoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma
-
Article
Open AccessPreoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma
The presence of microvascular invasion (MVI) is a critical determinant of early hepatocellular carcinoma (HCC) recurrence and prognosis. We developed a nomogram model integrating clinical laboratory examinatio...
-
Article
Positive association between lymphotoxin-alpha variation rs909253 and cancer risk: a meta-analysis based on 36 case–control studies
Lymphotoxin-alpha (LTA) polymorphism rs909253 has been reported to be a risk factor for cancers, but some results are inconsistent. To establish a more conclusive association, we performed a meta-analysis of t...
