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    Article

    Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines

    Inappropriate c-MET signaling in cancer can enhance tumor cell proliferation, survival, motility, and invasion. Inhibition of c-MET signaling induces apoptosis in a variety of cancers. It has also been recogni...

    T-H Hung, Y-H Li, C-P Tseng, Y-W Lan, S-C Hsu, Y-H Chen, T-T Huang in Cancer Gene Therapy (2015)

  2. Article

    Open Access

    hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

    Telomerase activity is suppressed in normal somatic tissues but is activated in most cancer cells. We have previously found that all six telomerase subunit proteins, including hTERT and hsp90 are needed for fu...

    J T Chang, Y-C Lu, Y-J Chen, C-P Tseng, Y-L Chen, C-W Fang in British Journal of Cancer (2006)